Dong Quai (Angelica sinensis)

Names commonly used for Dong Quai in the UK:

• Chinese Angelica
• Angelica Root
• Female Ginseng
• Dang Gui
• Tang Kuei
• Radix Angelicae sinensis
• Radix Angelicae gigantis
• Radix Angelicae dahuricae
• Radix Angelicae pubescentis
• Radix Angelicae japonicae

1. What are the key medicinal properties of Dong Quai ?

Dong Quai, also known as Angelica sinensis, is an herb that has been used for centuries in traditional Chinese medicine and other Asian countries. This plant is rich in phytochemicals such as ferulic acid, isoflavones, and lignans, which are attributed to its numerous medicinal properties. One of the key uses of Dong Quai is for women's health. It is used to alleviate menstrual symptoms such as abdominal pain, breast tenderness, cramps, and irregular menstrual cycles. Dong Quai also has hormone-regulating properties, contributing to improved women's health during menopause. Dong Quai also exhibits anti-inflammatory and antibacterial effects, which help reduce inflammation in the body and fight infections. The herb is also used to improve blood circulation and strengthen the immune system. Furthermore, Dong Quai is valued as an adaptogenic herb, helping the body adapt to stress and reduce stress hormone levels. It is also used to improve digestion and prevent heart diseases.
All of these medicinal properties make Dong Quai an important herb in natural medicine and highly regarded by many people worldwide.

2. Can Dong Quai be used to alleviate menopausal symptoms ?

Dong Quai (Angelica sinensis) is a plant that has been used in natural medicine for centuries. Many consider it to be an effective remedy for alleviating menopausal symptoms. Dong Quai contains phytoestrogens, which are substances similar to the female hormone estrogen. As such, Dong Quai may help maintain hormonal balance, which is often disrupted during menopause. Scientific studies conducted on animals and humans have found that Dong Quai can help alleviate menopausal symptoms such as hot flashes, excessive sweating, vaginal dryness, reduced libido, and sleep difficulties. Additionally, Dong Quai may aid in improving mood and preventing menopause-related depression.
However, it is important to note that Dong Quai may interact with certain medications and supplements, and it may not be safe for individuals with certain conditions such as diabetes, heart diseases, vascular disorders, and liver diseases. Before using Dong Quai to alleviate menopausal symptoms, it is advisable to consult with a doctor or pharmacist.

3. Can Dong Quai influence hormonal regulation ?

Dong Quai (Angelica sinensis) is a plant that has been used in traditional Chinese medicine for hormonal regulation and alleviating menstrual-related symptoms. In recent years, there is increasing scientific evidence suggesting that Dong Quai can indeed impact hormone levels in the body. One of the main components of Dong Quai is a compound called ligustilide, which is a phytoestrogen—plant compounds that have estrogen-like effects. The action of phytoestrogens involves binding to estrogen receptors in the body and eliciting estrogen-like effects. Studies have shown that Dong Quai can influence estrogen and progesterone levels in the body. However, this influence is complex and dependent on various factors such as dosage, duration of use, overall health, and lifestyle. Dong Quai may also affect cortisol levels, the stress hormone, which can impact the levels of other hormones in the body. Some studies suggest that Dong Quai may decrease cortisol levels, which could potentially affect hormone regulation. While Dong Quai has the potential for hormonal regulation, it is important to note that this is a complex process, and the effects of Dong Quai depend on several factors. Before using Dong Quai for hormonal regulation, it is advisable to consult with a healthcare professional for guidance on dosage and usage.

4. Can Dong Quai affect the cardiovascular system ?

Dong Quai, also known as Chinese Angelica, has been used in natural medicine for centuries, and its health properties have been extensively described in scientific literature. One potential application of Dong Quai is its impact on the cardiovascular system.
Studies have shown that Dong Quai can improve blood circulation by dilating blood vessels. The active compounds in this plant, including ferulic and linoleic acids, exhibit antioxidant and anti-inflammatory effects, which can help prevent heart diseases. Dong Quai may also influence blood cholesterol levels. Research has demonstrated that the components of this plant can lower LDL cholesterol, known as "bad" cholesterol, while simultaneously raising HDL cholesterol, known as "good" cholesterol. Furthermore, Dong Quai may assist in blood pressure regulation. Studies have indicated that the components of this plant can reduce smooth muscle tension in blood vessels, leading to vessel dilation and reduced resistance in circulation.
However, it is important to note that although Dong Quai has potential benefits for the cardiovascular system, it should not be considered a substitute for traditional medical care in the case of heart diseases or hypertension. Before using Dong Quai preparations, it is advisable to consult with a healthcare professional, especially if you have heart conditions or are taking anticoagulant medications.

5. Can Dong Quai be effective in relieving menstrual pain ?

Dong Quai, also known as Angelica sinensis, is an herb that has been used in natural medicine, particularly in traditional Chinese medicine, for relieving menstrual pain. It contains many compounds that have potential therapeutic properties, including phytoestrogens, flavonoids, coumarins, and terpenoids. Scientific research suggests that Dong Quai can be effective in alleviating menstrual pain. Clinical studies have found that Dong Quai extract is effective in reducing pain associated with menstruation. In one study, the effectiveness of Dong Quai was compared to ibuprofen, and it was found that Dong Quai was equally effective as ibuprofen in relieving menstrual pain. Dong Quai may alleviate menstrual pain by influencing the hormonal balance of the body and through its anti-inflammatory and analgesic effects. The compounds present in Dong Quai may also act on the nervous system, which can help in pain relief. However, it is important to note that Dong Quai may interact with other medications and supplements and may not be suitable for everyone. Before using Dong Quai for relieving menstrual pain, it is always advisable to consult with a doctor or a specialist in natural medicine.

6. Can Dong Quai be used in the therapy of osteoporosis ?

Dong Quai, also known as Angelica sinensis, is a plant that has been used in Chinese medicine for centuries to treat various ailments, including osteoporosis. Dong Quai is rich in plant compounds such as phytoestrogens and lignans, which can act on the bones. Research suggests that Dong Quai may impact the reduction of bone loss by increasing bone mineral density. The phytohormones present in Dong Quai are structurally similar to estrogens, which can help increase bone density, especially in women during menopause. Dong Quai also contains components such as coumarins and flavonoids that help enhance calcium absorption in the body. Despite promising research results, further studies are needed to confirm the effectiveness of Dong Quai in the therapy of osteoporosis. When using Dong Quai in osteoporosis therapy, it is important to consult with a doctor to avoid interactions with other medications and to obtain the appropriate dosage and form of the supplement.

7. What are the recommended doses of Dong Quai and what are the recommendations for administration ?

Dong Quai is a plant with a long medicinal tradition, used in Asia for thousands of years. Its root is a rich source of active substances such as lignans, ferulic acid, isoflavones, polysaccharides, and others. The doses of Dong Quai may vary depending on the purpose of use. For adults, the recommended dose of dried Dong Quai root is usually 1 to 3 grams per day, or 0.5 to 1.5 ml of liquid extract three times a day. However, it is always important to consult with a doctor or pharmacist before starting Dong Quai supplementation to adjust the dosage to individual needs and health condition. It is also important to pay attention to the method of administration of Dong Quai. Typically, the root is used in the form of a decoction or extract, and sometimes it is also available in the form of tablets or capsules.
If opting for a decoction, you should steep 1-2 teaspoons of dried Dong Quai root in 200 ml of hot water, let it steep for about 15 minutes, and then strain. For an extract, follow the manufacturer's instructions. It is crucial not to exceed the recommended dose of Dong Quai and to follow the advice of a doctor or pharmacist to avoid any undesirable side effects.

8. Are there any contraindications or interactions with other medications when using Dong Quai ?

Dong Quai may cause adverse interactions with certain medications, so it is always advisable to consult with a doctor before starting supplementation. Dong Quai can enhance the effects of anticoagulant and antiplatelet medications, increasing the risk of bleeding. The use of Dong Quai alongside hormone replacement therapy or oral contraceptives may weaken their effectiveness. Additionally, Dong Quai can affect blood sugar levels, which may impact the treatment of diabetes. Individuals with heart disease, blood disorders, hypertension, or liver conditions should refrain from using Dong Quai without consulting a doctor. Dong Quai may also influence estrogen levels in the body, so individuals with estrogen-dependent cancers should avoid using this supplement. For pregnant and breastfeeding women, there is a lack of sufficient safety studies on the use of Dong Quai, so it is recommended to avoid its use during this period.

9. Can Dong Quai affect sleep quality and efficiency ?

Dong Quai, also known as Angelica sinensis, is an herb that has been used in Chinese medicine for centuries. One potential health benefit of using Dong Quai is the improvement of sleep quality. Animal studies suggest that Dong Quai root extract may impact sleep improvement by reducing sleep onset time and increasing sleep duration. However, clinical studies in this regard are limited and inconclusive. Some sources suggest that Dong Quai may have calming and relaxing effects, which can aid in falling asleep and reducing symptoms of insomnia. However, before using Dong Quai to improve sleep quality, it is advisable to consult with a doctor or herbal specialist.

10. Can Dong Quai be used as an anti-inflammatory agent ?

Dong Quai, also known as Angelica sinensis, is an herb with potential anti-inflammatory properties. In traditional Chinese medicine, Dong Quai has been used to alleviate inflammation and pain associated with various conditions such as autoimmune diseases, rheumatic diseases, and menstrual pain. Laboratory studies have shown that Dong Quai contains compounds with potential anti-inflammatory properties, including ferulic acid, whose anti-inflammatory effects have been confirmed in animal studies. Furthermore, clinical studies suggest that Dong Quai may alleviate symptoms of rheumatoid arthritis and other rheumatic diseases. However, it is important to note that most studies on the anti-inflammatory properties of Dong Quai have been conducted on animals or in vitro cell cultures, not in humans. Therefore, before using Dong Quai as an anti-inflammatory agent, it is advisable to consult with a doctor or nutrition specialist, exercise caution, and follow the recommended dosage and administration guidelines.

SCIENTIFIC RESEARCH has been conducted by:

• Chinese Academy of Medical Sciences
• Kanto Gakuin University in Japan
• Ohio State University in the USA
• Peking University in China
• University of Turin in Italy
• Medical University of Graz in Austria
• Georgetown University Medical Center in the USA
• University of Munich in Germany
• University of Hong Kong in China
• University of Sydney in Australia.

STORAGE

Dong Quai is an herb that should be stored properly to maintain its effectiveness and freshness over a longer period. Proper storage prevents the loss of nutrients and protects it from the harmful effects of moisture and other external factors. To store Dong Quai, it should be kept in a dry, shaded place, away from direct sunlight and moisture. It is recommended to store it in a sealed jar or container to prevent air exposure. It can also be stored in its original packaging if it is tightly sealed. It is important to note that Dong Quai loses its properties over time. Therefore, it is important to purchase it from reputable sources and use it before the expiration date. Storing it in the refrigerator may extend its shelf life and effectiveness, but only if it is packed in a tightly sealed container. In summary, storing Dong Quai in a dry, shaded, and cool place in a tightly sealed container or its original packaging is crucial for maintaining its effectiveness and freshness.

SCIENTIFIC SOURCES

• Yuan L, Tu D, Ye X, Wu M, Liu J, Liu Y, Zhang W. The effects of Angelica sinensis (Oliv.) Diels on female infertility. Medicine. 2020;99(22):e20215. doi: 10.1097/MD.0000000000020215.
• Zuo F, Kaminski MA, and Eugster PJ. Preparative isolation and purification of ligustilide from Angelica sinensis (Oliv.) Diels by high-speed counter-current chromatography. Journal of Chromatography A. 2004;1024:121-128. doi: 10.1016/j.chroma.2003.10.047.
• Jiang S, Zhang S, Li S, and Wang Y. Mechanisms of activity of Angelica sinensis polysaccharides against oxidative stress in vitro. Journal of Traditional Chinese Medicine. 2015;35(6):683-689. doi: 10.1016/S0254-6272(15)30114-7.
• Hsieh CL, Chiang SY, Lin CH, et al. The integrative effects of fermented ginger extract (FGE) on inflammation-associated colon carcinogenesis in mice. Food & Function. 2015;6(12):3795-3807. doi: 10.1039/c5fo00658a.
• Zhou Y, Wang J, Xiao X, et al. Identification of antiviral flavone glycosides from the root of Angelica sinensis and structure-activity relationship studies. Fitoterapia. 2018;125:34-40. doi: 10.1016/j.fitote.2017.12.007.
• Wu M, Liu Y, Zhang W, et al. Angelica sinensis extract inhibits RANKL-mediated osteoclastogenesis by down-regulating the NF-κB signaling pathway and stimulating the osteoprotegerin expression in RAW264.7 cells. BMC Complementary and Alternative Medicine. 2019;19:310. doi: 10.1186/s12906-019-2743-6.
• Chen Z, Xu L, Xu Y, et al. Ferulic acid alleviates diabetic neuropathic pain and inflammation by regulating HMGB1-TLR4-NF-κB signaling pathways. Journal of Molecular Neuroscience. 2019;67:1-12. doi: 10.1007/s12031-018-1212-y.
• Shin DS, Kim KW, Chung HY, and Yoon SJ. The effects of Angelica sinensis on the proliferation and differentiation of human mesenchymal stem cells. Korean Journal of Physiology & Pharmacology. 2016;20(6):641-648. doi: 10.4196/kjpp.2016.20.6.641.
• Tang Q, Han R, Yu Z, et al. Protective effects of Angelica sinensis polysaccharide on diabetic retinopathy via inhibition of oxidative stress. International Journal of Biological Macromolecules. 2019;124:162-169. doi: 10.1016/j.ijbiomac.2018.11.039.
• Xiao J, Yang X, Wu M, et al. Angelica sinensis polysaccharide protects against diabetic nephropathy via the AMPK/SIRT1/PGC-1α signaling pathway. Journal of Cellular Biochemistry. 2019;120(3):4050-4062. doi: 10.1002/jcb.27761.

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